The authors’ aim and purpose for doing the concept analysis on this topic are to clarify the concept of cancer-related psychological distress which is separate from non-cancer-related psychological distress. The authors also aim at promoting the use of the term in nursing practice and research when talking about cancer care. According to the authors, while psychological distress refers to the negative feelings or emotions affecting a person’s daily function, cancer-related psychological distress is different in that it could cause major psychiatric illness and symptoms of depression that are caused by the cancer diagnosis.